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  1. Dojind Reply
    An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat is thought to elicit toxicity through RNA mediated protein sequestration and repeat-associated non-AUG (RAN) translation of dipeptide repeat proteins (DPRs). We generated a series of transgenic Drosophila models expressing GGGGCC.
  2. Kishicage Reply
    The breast cancer resistance protein (BCRPABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. We show here that mice lacking Bcrp1Abcg2 become extremely sensitive to the dietary chlorophyll-breakdown product pheophorbide a, r .
  3. Tura Reply
    Different renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats. Lloberas N(1), Torras J, Alperovich G, Cruzado JM, Giménez-Bonafé P, Herrero-Fresneda I, Franquesa Ml, Rama I, Grinyó JM.
  4. Fegul Reply
    The most complex path to toxicity involves more steps (Figure 3–1).First, the toxicant is delivered to its target or targets (step 1), interacting with endogenous target molecules (step 2a) or altering the environment (step 2b), triggering perturbations in cell function and/or structure (step 3), which initiate repair mechanisms at the molecular, cellular, and/or tissue levels (step 4).
  5. Vozshura Reply
    This chart explores the many products that are commonly made from the seven different types of plastics and the properties that differentiate them. It also takes a hard look at the toxicity of each of the seven types of plastic to determine which are the safest and which should be avoided at all costs.
  6. Durr Reply
    View credits, reviews, tracks and shop for the CD release of Toxic on Discogs/5(6).
  7. Diramar Reply
    According to Olmstead and LeBlanc's () integrated addition model, like acting chemicals are assigned to a common cassette (i.e., grouping). Toxicity associated with the cassette is then calculated using a concentration addition approach. Accordingly, malathion and parathion were assigned to a common cassette, the organophosphate (OP) cassette.
  8. Vut Reply
    MRP1 (ABCC1) is a peculiar member of the ABC transporter superfamily for several aspects. This protein has an unusually broad substrate specificity and is capable of transporting not only a wide variety of neutral hydrophobic compounds, like the MDR1/P-glycoprotein, but also facilitating the extrusion of numerous glutathione, glucuronate, and sulfate conjugates.